CIP is widely utilized for cleaning bioreactors, fermenters, mixing vessels, and other equipment in biotechnology, pharmaceutical, and food and beverage manufacturing. This process eliminates components from previous cell culture batches, removes in-process residues, controls bioburden, and reduces endotoxin levels in processing equipment and systems.

Residue removal during CIP relies on a combination of heat, chemical action, and turbulent flow. Ensuring reliable, repeatable, and effective cleaning is crucial for maintaining operational standards in manufacturing facilities. Cleaning procedures are validated to confirm their effectiveness, reproducibility, and control.